The Arandjelovic laboratory research focus is on cell clearance in inflammatory disease, using rheumatoid arthritis (RA) and multiple sclerosis (MS) as model systems
Research Summary
Inflammatory states are associated with high rates of cell death, mostly through apoptosis, and the clearance of apoptotic cells is a critical step in disease pathology. However, the cellular identity of phagocytes and the molecular events that contribute to the clearance of apoptotic cells has been understudied in many inflammatory diseases. In other words, “who” are the cleaning crew and which “tools” are they using?
Current Projects
Function of the engulfment regulator ELMO1 in inflammation
Disease contribution and therapeutic potential of cell clearance pathways in autoimmune inflammation
